Mutational-based medicine in breast cancer

Mutational-based medicine in breast cancer


dr. M. Balic, clinical oncologist

dr. C.W. Menke-van der Houven van Oordt, medical oncologist

prof. dr. M.J. van de Vijver, pathologist

Date:                 december 2020

Remarkable progress in sequencing technology over the past two decades has made it possible to profile tumors and identify clinically relevant genetic alterations. In breast cancer, the use of this technology has helped identifying key alterations in the PI3K pathway and PIK3CA gene which, in turn, have led to the development of several drugs targeting these alterations. In this Pharmacotherapy-Online Video Special on mutational-based medicine in breast cancer three specialists, Prof. dr. van de Vijver, Dr. Balic and Dr. Menke, each highlight different aspects of this new development in breast cancer treatment.